Author/Authors :
Tong، نويسنده , , J.H.M and To، نويسنده , , K.F and Ng، نويسنده , , E.K.W and Lau، نويسنده , , J.Y.W and Lee، نويسنده , , T.L and Lo، نويسنده , , K.W and Leung، نويسنده , , Ronald W.K. and Tang، نويسنده , , N.L.S and Chan، نويسنده , , F.K.L and Sung، نويسنده , , J.J.Y and Chung، نويسنده , , S.C.S، نويسنده ,
Abstract :
We screened 90 cases of gastric carcinoma (GCA) samples for β-catenin exon 3 mutation and assessed its possible relationship with microsatellite instability (MSI). Three mutations were detected in two samples, including a single mutation in an intestinal type and double mutations in a diffuse type GCA. One of the mutations found in the diffuse type GCA sample was a non-sense mutation at codon 68 (CAG→TAG). This novel mutation was predicted to disrupt the binding of β-catenin to α-catenin and may be related to the diffuse type morphology. The other two mutations were missense mutations involved or related to the GSK-3β phosphorylation site, which have been reported previously. No MSI can be demonstrated in the two cases with β-catenin mutation. Our results suggested that β-catenin mutation was infrequent in GCA and appeared not specific for MSI.
