Author/Authors :
Shinomiya، نويسنده , , Sachiko and Sasaki، نويسنده , , Jun and Kiyohara، نويسنده , , Chikako and Tsuji، نويسنده , , Emiko and Inoue، نويسنده , , Hisako and Marugame، نويسنده , , Tomomi and Handa، نويسنده , , Koichi and Hayabuchi، نويسنده , , Hitomi and Hamada، نويسنده , , Hiroaki and Eguchi، نويسنده , , Hiroyuki and Fukushima، نويسنده , , Yoshitaka and Kono، نويسنده , , Suminori، نويسنده ,
Abstract :
We examined the relation of serum lipids and apolipoprotein E genotype to colorectal adenomas among 205 cases and 220 controls with normal colonoscopy in Japanese men. With adjustment for body mass index, cigarette smoking, alcohol use, and other covaiates, odds ratios of proximal and distal adenomas associated with the presence of an allele ε4 were 0.59 (95% confidence interval 0.23–1.45) and 0.99 (0.50–1.98), respectively. While serum total and LDL cholesterol were unrelated to both proximal and distal adenomas, serum triglycerides were positively related to distal adenomas. The findings suggest that altered lipid metabolism may be differentially associated with tumorigenesis in the proximal and distal colorectum.
