Author/Authors :
Okuda، نويسنده , , Toyokazu and Wakasa، نويسنده , , Kenichi and Kubo، نويسنده , , Shoji and Hamada، نويسنده , , Tomomi and Fujita، نويسنده , , Masami and Enomoto، نويسنده , , Takayuki and Haba، نويسنده , , Tomoko and Hirohashi، نويسنده , , Kazuhiro and Kinoshita، نويسنده , , Hiroaki، نويسنده ,
Abstract :
To investigate the monoclonality of hepatocellular carcinoma (HCC) and dysplastic nodule (DN) and the origin of multiple lesions, patterns of inactivation of X-linked human androgen receptor gene were studied. Fourteen of 15 patients (93%) were heterozygous in the size of the target, and were informative for clonal analysis. Monoclonal composition was demonstrated in all 17 HCCs and two DNs, whereas all non-cancerous hepatic tissues were polyclonal. Of four patients with more than two lesions of HCC or DN, two patients had two lesions with different patterns of X-chromosome inactivation, indicating that the two lesions were multicentric in origin.
Keywords :
Methylation pattern of X-chromosome , hepatocellular carcinoma , Human androgen receptor gene , Multicentric carcinogenesis , Dysplastic nodule
