Title of article
Clonal analysis of hepatocellular carcinoma and dysplastic nodule by methylation pattern of X-chromosome-linked human androgen receptor gene
Author/Authors
Okuda، نويسنده , , Toyokazu and Wakasa، نويسنده , , Kenichi and Kubo، نويسنده , , Shoji and Hamada، نويسنده , , Tomomi and Fujita، نويسنده , , Masami and Enomoto، نويسنده , , Takayuki and Haba، نويسنده , , Tomoko and Hirohashi، نويسنده , , Kazuhiro and Kinoshita، نويسنده , , Hiroaki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
6
From page
91
To page
96
Abstract
To investigate the monoclonality of hepatocellular carcinoma (HCC) and dysplastic nodule (DN) and the origin of multiple lesions, patterns of inactivation of X-linked human androgen receptor gene were studied. Fourteen of 15 patients (93%) were heterozygous in the size of the target, and were informative for clonal analysis. Monoclonal composition was demonstrated in all 17 HCCs and two DNs, whereas all non-cancerous hepatic tissues were polyclonal. Of four patients with more than two lesions of HCC or DN, two patients had two lesions with different patterns of X-chromosome inactivation, indicating that the two lesions were multicentric in origin.
Keywords
Methylation pattern of X-chromosome , hepatocellular carcinoma , Human androgen receptor gene , Multicentric carcinogenesis , Dysplastic nodule
Journal title
Cancer Letters
Serial Year
2001
Journal title
Cancer Letters
Record number
1802266
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