Title of article
Differential anthracycline sensitivity in two related human colon carcinoma cell lines expressing similar levels of P-glycoprotein
Author/Authors
Boquete، نويسنده , , Alejandra L and Vargas Roig، نويسنده , , Laura and Lَpez، نويسنده , , Gustavo A and Gude، نويسنده , , Rajiv and Binda، نويسنده , , M.Mercedes and Gonzلlez، نويسنده , , Alejandro D and Ciocca، نويسنده , , Daniel R and Bonfil، نويسنده , , R.Daniel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
6
From page
111
To page
116
Abstract
Chemosensitivity of the human colon carcinoma HCT-15 cell line to 4′-epidoxorubicin proved to be 100-fold higher than that of its variant HCT-15 EDR. Confocal scanning microscopy showed significant less drug accumulation in HCT-15 EDR. A 2-fold increase in hsp27 expression was found in HCT-15 EDR, with no alteration in hsp70. The expression of the drug exporter Pgp was similar in both cell lines, despite the lower drug accumulation shown by HCT-15 EDR in respect to HCT-15. Other molecules implicated in the acquisition of enhanced chemoresistance or a more active Pgp variant present in HCT-15 EDR, could explain the phenomenon.
Keywords
Multidrug resistance , P-GLYCOPROTEIN , colon carcinoma , 4?-Epidoxorubicin , anthracyclines , Heat Shock Proteins
Journal title
Cancer Letters
Serial Year
2001
Journal title
Cancer Letters
Record number
1802383
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