Title of article
Alteration of cyclin D1 and CDK4 gene in carcinoma of uterine cervix
Author/Authors
Cheung، نويسنده , , Tak Hong and Yu، نويسنده , , May Mei Yung and Lo، نويسنده , , Keith Wing Kit and Yim، نويسنده , , So Fan and Chung، نويسنده , , Tony Kwok Hung and Wong، نويسنده , , Yick Fu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
8
From page
199
To page
206
Abstract
Amplification and overexpression of cyclin D1 and CDK4 genes in cervical carcinoma were studied by semi-quantitative differential polymerase chain reaction assay and an immunostaining technique, respectively. Amplifications of cyclin D1 and CDK4 genes were found in 24% (27/113) and 26% (29/112) of tumors, respectively. Overexpression of cyclin D1 and CDK4 was demonstrated in 32% (21/66) and 73% (45/62) of tumors, respectively. No tumor showed CDK4 gene mutation on single strand conformational polymorphism. Sixteen percent (8/49) of the tumor specimens showed neither amplification nor overexpression. Disease stage, tumor grade and overexpression of cyclin D1 were found to be independent poor prognostic factors in cervical carcinoma.
Keywords
cdk4 , Retinoblastoma gene , cyclin D1 , Cervical carcinoma , Prognosis
Journal title
Cancer Letters
Serial Year
2001
Journal title
Cancer Letters
Record number
1802524
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