Title of article
Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid
Author/Authors
Igal Teplitzky، نويسنده , , S.R. and Kiefer، نويسنده , , T.L. and Cheng، نويسنده , , Q. and Dwivedi، نويسنده , , P.D. and Moroz، نويسنده , , K. and Myers، نويسنده , , L. and Anderson، نويسنده , , M.B. and Collins، نويسنده , , A. and Dai، نويسنده , , J. and Yuan، نويسنده , , Cynthia L. and Spriggs، نويسنده , , L.L. and Blask، نويسنده , , D.E. and Hill، نويسنده , , S.M.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2001
Pages
9
From page
155
To page
163
Abstract
In experimental trials using the N-nitroso-N-methylurea (NMU)-induced rat mammary tumor model, a significant decrease in tumor incidence (to 5%) was observed in rats treated with melatonin and 9-cis-retinoic acid (9 cRA) compared to controls (55%). Although 9cRA alone decreased tumor incidence to 26%, this response did not reach statistical significance. Tumor incidence was significantly inhibited to 20% in the animals that received melatonin and 9cRA on alternating days. Latency to tumor onset was prolonged in animals receiving either of the combination treatments compared with controls, and tumor multiplicity was also significantly decreased.
Keywords
melatonin , 9-cis-Retinoic acid , breast cancer
Journal title
Cancer Letters
Serial Year
2001
Journal title
Cancer Letters
Record number
1802749
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