Author/Authors :
Maoka، نويسنده , , Takashi and Mochida، نويسنده , , Kooich and Kozuka، نويسنده , , Mutsuo and Ito، نويسنده , , Yoshihiro and Fujiwara، نويسنده , , Yasuhiro and Hashimoto، نويسنده , , Keiji and Enjo، نويسنده , , Fumio and Ogata، نويسنده , , Masakazu and Nobukuni، نويسنده , , Yoshitoshi and Tokuda، نويسنده , , Harukuni and Nishino، نويسنده , , Hoyoku، نويسنده ,
Abstract :
Capsanthin (1) and related carotenoids (2–7) isolated from the fruits of red paprika Capsicum annuum L. showed potent in vitro anti-tumor-promoting activity with inhibitory effects on Epstein–Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Among them, capsanthin diester (3) and capsorbin diester (5) showed strong inhibitory effects. Furthermore, capsanthin (1), capsanthin 3′-ester (2) and capsanthin 3,3′-diester (3), major carotenoids in paprika, exhibited potent anti-tumor-promoting activity in an in vivo mouse skin two-stage carcinogenesis assay using 7, 12-dimethylbenz[a]anthracene as an initiator and TPA as a promoter.
Keywords :
Capsicum annuum , capsanthin , Cancer chemopreventive activity , Early antigen two-stage mouse skin carcinogenesis , Epstein–Barr virus , carotenoid
