Title of article :
Increased expression of sialyl Lewisx antigen as a prognostic factor in patients with stage 0, I, and II gastric cancer
Author/Authors :
Nakagoe، نويسنده , , Tohru and Fukushima، نويسنده , , Kiyoyasu and Sawai، نويسنده , , Terumitsu and Tsuji، نويسنده , , Takashi and Jibiki، نويسنده , , Masa-aki and Nanashima، نويسنده , , Atsushi and Tanaka، نويسنده , , Kenji and Yamaguchi، نويسنده , , Hiroyuki and Yasutake، نويسنده , , Toru and Ayabe، نويسنده , , Hiroyoshi and Arisawa، نويسنده , , Kokichi and Ishikawa، نويسنده , , Hiroshi، نويسنده ,
Abstract :
Immunohistochemically detected expression of sialyl Lewisx (Lex) antigen was analyzed in 101 stage 0–II gastric cancers to clarify its prognostic value after curative gastrectomy. Patients with a high-expression of sialyl Lex antigen within their tumors had shorter disease-specific intervals than those with negative- or low-expressing tumors (P<0.0001). This difference was noted particularly in stage I-B or II disease. Multivariate Coxʹs regression analysis revealed sialyl Lex antigen expression to be an independent predictor of disease-specific survival (Hazard ratio=9.10). In conclusion, the increased expression of sialyl Lex antigen may serve as a prognostic factor after curative surgery for stages 0–II gastric cancer.
