Title of article :
Cancer chemopreventive effects of constituents of Caesalpinia ferrea and related compounds
Author/Authors :
Nakamura، نويسنده , , Eliane S and Kurosaki، نويسنده , , Fumiya and Arisawa، نويسنده , , Munehisa and Mukainaka، نويسنده , , Teruo and Okuda، نويسنده , , Masato and Tokuda، نويسنده , , Harukuni and Nishino، نويسنده , , Hoyoku and Pastore Jr.، نويسنده , , Floriano، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Abstract :
Summary
ti-tumor promoting effects of fruits of Caesalpinia ferrea Mart. (Leguminosae) were tested by the in vitro Epstein–Barr virus early antigen (EBV-EA) activation assay, and its active constituents were identified as gallic acid (1) and methyl gallate (2). A total of 49 related compounds of 1 and 2 were analysed for the effects by this assay, and the structure activity relationships have been proposed. Three acetophenone derivatives, 2,6-dihydroxyacetophenone (48), 2,3,4-trihydroxyacetophenone (50) and 2,4,6-trihydroxy- acetophenone (51) were found to show potent inhibitory activity.
Keywords :
EBV-EA activation assay , Anti-tumor promotion , acetophenone , Caesalpinia ferrea , Gallic acid , Methyl gallate
Journal title :
Cancer Letters
Journal title :
Cancer Letters
