Author/Authors :
Uenishi، نويسنده , , Takahiro and Kubo، نويسنده , , Shoji and Hirohashi، نويسنده , , Kazuhiro and Yamamoto، نويسنده , , Takatsugu and Ogawa، نويسنده , , Masao and Tanaka، نويسنده , , Hiromu and Shuto، نويسنده , , Taichi and Kinoshita، نويسنده , , Hiroaki، نويسنده ,
Abstract :
The clinicopathologic findings in patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) positive for biliary markers, those related to the hepatic progenitor cells, were investigated. Cytokeratin (CK) 19 was reactive for HCCs only in patients with prior hepatitis B virus (HBV) infection. The proportions of patients with prior HBV infection and poorly differentiated HCC were significantly higher among those with CK 19-positive HCC than among those with CK 19-negative HCC. Some HCCs develop from the hepatic progenitor cells in patients with HCV infection and prior HBV infection, which may affect the clinicopathologic findings of HCV-related HCCs.
Keywords :
hepatitis B virus , Cytokeratin 7 , hepatocellular carcinoma , Cytokeratin 19
