Title of article
Synthesis and cytotoxicity of the dihydrated complex of oxaliplatin
Author/Authors
Videhult، نويسنده , , Pernilla and Yachnin، نويسنده , , Jeffrey and Jerremalm، نويسنده , , Elin and Lewensohn، نويسنده , , Rolf and Ehrsson، نويسنده , , Hans، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
191
To page
194
Abstract
A new way of synthesizing the dihydrated oxaliplatin complex (DOC) is presented and its cytotoxicity is compared to that of oxaliplatin and cisplatin. By hydrolyzing oxaliplatin in aqueous sodium hydroxide at 70°C, DOC was formed in less than 1 h. Cytotoxicity was studied in the non-small cell lung cancer cell line A549 using the fluorescent microculture cytotoxic assay. Oxaliplatin and cisplatin had similar cytotoxicity profiles, whereas DOC was found to be considerably more toxic. The cytotoxicity of oxaliplatin might, at least in part, be mediated through the formation of DOC.
Keywords
Lung cancer cell line , Oxaliplatin , Aquated product , cytotoxicity
Journal title
Cancer Letters
Serial Year
2002
Journal title
Cancer Letters
Record number
1803916
Link To Document