Title of article
Frameshift mutations in the MBD4/MED1 gene in primary gastric cancer with high-frequency microsatellite instability
Author/Authors
Yamada، نويسنده , , Tatsuya and Koyama، نويسنده , , Toru and Ohwada، نويسنده , , Susumu and Tago، نويسنده , , Ken-ichi and Sakamoto، نويسنده , , Ichiro and Yoshimura، نويسنده , , Sumihiko and Hamada، نويسنده , , Kunihiro and Takeyoshi، نويسنده , , Izumi and Morishita، نويسنده , , Yasuo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
6
From page
115
To page
120
Abstract
MBD4/MED1 is a newly identified mismatch repair gene, which is mutated in colon, endometrial, and pancreatic high-frequency microsatellite instability (MSI-H) tumors. To assess its role in gastric cancers, we investigated MBD4/MED1 mutations in sporadic gastric cancers, compared with colon cancers. Frameshift mutations were found in 29% of gastric and 20% of colon MSI-H cancers, but not in any low-frequency microsatellite instability/microsatellite stable cancers. MBD4/MED1 is mutated in gastric cancers as frequently as in colon cancers; these mutations reduce the accuracy of DNA repair, and may lead to cancer progression.
Keywords
MBD4 , microsatellite instability , Gastric cancer , Colon cancer , mismatch repair , mutator phenotype , MED1
Journal title
Cancer Letters
Serial Year
2002
Journal title
Cancer Letters
Record number
1803996
Link To Document