Title of article :
CYP1A1, GSTM1, and GSTT1 polymorphisms and breast cancer risk in Brazilian women
Author/Authors :
da Fonte de Amorim، نويسنده , , L??dia Maria and Rossini، نويسنده , , Ana and Mendonça، نويسنده , , Gulnar Azevedo Silva and Lotsch، نويسنده , , Priscila Falagan and de Almeida Sim?o، نويسنده , , Tatiana and de Moura Gallo، نويسنده , , Cl?udia Vit?ria and Pinto، نويسنده , , Luis Felipe Ribeiro and Pestana، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Abstract :
The frequency of CYP1A1 (CYP1A1*2A), GSTM1, and GSTT1 polymorphisms, as well as the main risk factors associated with breast cancer were studied in Brazilian women, with malignant breast cancer (n=128), or age-matched controls (n=256). Only a family history of breast cancer presented a significant risk (OR=3.00, CI=1.27–7.06). Among non-whites, the CYP1A1*2A allele was underrepresented among patients. Statistical analysis indicated that this polymorphism may decrease the risk of breast cancer among these individuals, particularly after adjusting for the risk presented by selected risk factors (OR=0.30, 95% CI=0.12–0.76).
Keywords :
breast , CYP1A1 , Glutathione S-transferases , Polymorphism , cancer
Journal title :
Cancer Letters
Journal title :
Cancer Letters
