Title of article :
Flaxseed inhibits metastasis and decreases extracellular vascular endothelial growth factor in human breast cancer xenografts
Author/Authors :
Charlotta Dabrosin، نويسنده , , Charlotta and Chen، نويسنده , , Jianmin and Wang، نويسنده , , Linda and Thompson، نويسنده , , Lilian U، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Abstract :
Angiogenesis is important in tumor growth, progression and metastatic dissemination. Vascular endothelial growth factor (VEGF) is one key factor in promotion of breast cancer angiogenesis. VEGFs are bioactive in the extracellular space where they become available to the endothelial cells. Phytoestrogens such as lignans have been shown to alter breast cancer incidence and be cancer-protective in rats. We show that supplementation of 10% flaxseed, the richest source of mammalian lignans, to nude mice with established human breast tumors reduced tumor growth and metastasis. Moreover, flaxseed decreased extracellular levels of VEGF, which may be one mechanistic explanation to the decreased tumor growth and metastasis.
Keywords :
microdialysis , flaxseed , metastasis , MDA-MB-435 , Angiogenesis , Vascular endothelial growth factor
Journal title :
Cancer Letters
Journal title :
Cancer Letters