Author/Authors :
Colombo، نويسنده , , Diego and Compostella، نويسنده , , Federica and Ronchetti، نويسنده , , Fiamma and Reza-Elahi، نويسنده , , Shahrzad and Scala، نويسنده , , Antonio and Toma، نويسنده , , Lucio and Aoi، نويسنده , , Wataru and Kuchide، نويسنده , , Masashi and Takayasu، نويسنده , , Junko and Tokuda، نويسنده , , Harukuni and Nishino، نويسنده , , Hoyoku، نويسنده ,
Abstract :
Nine new synthetic compounds, structurally related to the most active glycoglycerolipid analogues carrying a hexanoyl chain, were tested for their anti-tumor-promoting activity using a short-term in vitro assay for Epstein–Barr virus (EBV) activation. All these compounds, in which the ester function is replaced by different metabolically more stable groups, were almost as active as their ester reference compounds in inhibiting the EBV activation promoted by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Two of these, devoid of any functionality on the lipophilic chain, when tested in an in vivo two-stage carcinogenesis test, exhibited marked inhibitory effects on mouse skin tumor promotion.
Keywords :
glycoglycerolipids , cancer chemoprevention , Epstein–Barr virus , 12-O-Tetradecanoylphorbol-13-acetate , Two-stage skin carcinogenesis test
