Title of article :
Sera from cancer patients contain two oscillating ECTO-NOX activities with different period lengths
Author/Authors :
Wang، نويسنده , , Sui and Morré، نويسنده , , Dorothy M. and Morré، نويسنده , , D.James، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Pages :
7
From page :
135
To page :
141
Abstract :
ECTO-NOX protein’s are cell surface-associated and growth-related hydroquinone oxidases with both protein disulfide-thiol interchange activity and the capacity to oxidize NAD(P)H. The activities of these ECTO-NOX proteins are not steady state but fluctuate to create a repeating pattern of oscillations. Two forms of ECTO-NOX activities have been distinguished. The constitutive ECTO-NOX (CNOX), is hormone responsive and refractory to quinone-site inhibitors. A tumor-associated NOX (tNOX) is unregulated, refractory to hormones and growth factors and responds to quinone-site inhibitors. CNOX proteins are widely distributed and exhibit oscillations in enzymatic activity with a period length of 24 min. tNOX proteins are cancer specific and exhibit oscillations with a period length of about 22 min. Our findings now demonstrate the presence of the novel oscillating tNOX activity in sera of patients with cancer whereas the constitutive NOX of non-cancer cells is present in sera of both cancer patients and healthy volunteers. We conclude that ECTO-NOX proteins in sera exhibit oscillatory characteristics similar to those of ECTO-NOX forms of the cell surface.
Keywords :
Hydroquinone oxidase , Tumor-associated plasma membrane-located hydroquinone oxidase with protein disulfide-thiol interchange activity , ECTO-plasma membrane-located hydroquinone oxidase with protein disulfide-thiol interchange activity , SERA , CANCER , Constitutive plasma membrane-located hydroquinone oxidase with protein disulfide-thiol interchange activity
Journal title :
Cancer Letters
Serial Year :
2003
Journal title :
Cancer Letters
Record number :
1804676
Link To Document :
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