Author/Authors :
Tawara، نويسنده , , Masayuki and Maeda، نويسنده , , Takahiro and Yamada، نويسنده , , Yasuaki and Harasawa، نويسنده , , Hitomi and Tsuruda، نويسنده , , Kazuto and Sugahara، نويسنده , , Kazuyuki and Moriuchi، نويسنده , , Ryozo and Tomonaga، نويسنده , , Masao and Kamihira، نويسنده , , Shimeru Kamihira، نويسنده ,
Abstract :
In adult T-cell leukemia (ATL), tumor cells commonly express abundant membrane-bound Fas antigen. We reported a significant correlation between Fas expression status of ATL patients and their clinical outcome. In the current study, we analyzed the Fas cDNA sequence of the distinctive ATL cases that barely expressed mFas identified during the previous study. According to the results, changes in the Fas amino acid sequence were deduced in two of seven cases. Furthermore, we identified seven novel variants of Fas mRNA produced by alternative splicing. Our data indicates the diversity of Fas gene expression at a mRNA level in ATL.
Keywords :
Alternative splicing , Variant transcripts , Adult T-cell leukemia , Mutation , RNA processing , Fas
