Author/Authors :
Suzuki، نويسنده , , Kazuhiro and Matsui، نويسنده , , Hiroshi and Nakazato، نويسنده , , Haruki and Koike، نويسنده , , Hidekazu and Okugi، نويسنده , , Hironobu and Hasumi، نويسنده , , Masaru and Ohtake، نويسنده , , Nobuaki and Nakata، نويسنده , , Seiji and Takei، نويسنده , , Tomoyuki and Hatori، نويسنده , , Motoaki and Ito، نويسنده , , Kazuto and Yamanaka، نويسنده , , Hidetoshi، نويسنده ,
Abstract :
Association between genetic polymorphisms of CYP1A1 and familial prostate cancer risk was examined by a case-control study of 185 individuals. Although the individual analysis of m1 or m2 genotype of CYP1A1 showed no significant association with prostate cancer risk, the presence of any mutated alleles significantly increased prostate cancer risk in comparison with wild-type genotypes by combination analysis (odds ratio [OR]=2.38; 95% confidence interval [CI]=1.72-3.29; P=0.0069). Furthermore, metastatic cancer had a significant association with mutated alleles of m1 and m2. These finding suggested that CYP1A1 polymorphisms has an association with prostate cancer risk, especially with progression of prostate cancer.
Keywords :
CYP1A1 , genetic polymorphism , Familial prostate cancer , Japanese
