Author/Authors :
Isomoto، نويسنده , , Hajime and Oka، نويسنده , , Mikio and Yano، نويسنده , , Yoshitsugu and Kanazawa، نويسنده , , Yusei and Soda، نويسنده , , Hiroshi and Terada، نويسنده , , Ryusuke and Yasutake، نويسنده , , Toru and Nakayama، نويسنده , , Toshiyuki and Shikuwa، نويسنده , , Saburo and Takeshima، نويسنده , , Fuminao and Udono، نويسنده , , Heiichiro and Murata، نويسنده , , Ikuo and Ohtsuka، نويسنده , , Kenzo and Kohno، نويسنده , , Shigeru، نويسنده ,
Abstract :
Heat shock proteins (Hsp) 70 and Hsp 40 are stress proteins that cooperate as chaperones in mammalian cells. We determined the expression of Hsp 70 and Hsp 40 in 81 gastric cancers. Immunoreactivities to Hsp 70 and Hsp 40 were detected in 67.9 and 22.2% of tumors, respectively. Immunohistochemical analysis showed enhanced Hsp 70 and Hsp 40 expression in gastric tumor tissue, relative to the surrounding normal tissue. Overexpression of Hsp 70 and Hsp 40 was also confirmed by immunoblotting. Among various clinicopathological parameters, low histopathological differentiation was associated with reduced expression of both proteins.
Keywords :
heat shock protein 70 , Gastric cancer , Heat shock protein 40 , immunohistochemistry , Immunoblot
