Author/Authors :
Ishimura، نويسنده , , Norihisa and Yamasawa، نويسنده , , Kunihiro and Rumi، نويسنده , , Mohammad Azharul Karim and Kadowaki، نويسنده , , Yasunori and Ishihara، نويسنده , , Shunji and Amano، نويسنده , , Yuji and Nio، نويسنده , , Yoshinori and Higami، نويسنده , , Tetsuya and Kinoshita، نويسنده , , Yoshikazu، نويسنده ,
Abstract :
We investigated the frequency of BRAF mutations in human pancreatic cancer specimens to determine its role in the development of pancreatic cancer. Nine pancreatic cancer samples without a K-ras codon 12 mutation and 19 with a K-ras mutation were included in the study. Analyses of the BRAF sequence revealed mutations in exon 15 (V599E) in two cases, both of which also exhibited a K-ras codon 12 mutation. No BRAF mutation was found in cases without a K-ras mutation. The BRAF V599E mutation was not found to be a major mutation in pancreatic cancers that had no K-ras codon 12 mutation.
Keywords :
pancreatic cancer , BRAF , K-ras , Mutation , Serine/threonine kinase
