Title of article
BRAF and K-ras gene mutations in human pancreatic cancers
Author/Authors
Ishimura، نويسنده , , Norihisa and Yamasawa، نويسنده , , Kunihiro and Rumi، نويسنده , , Mohammad Azharul Karim and Kadowaki، نويسنده , , Yasunori and Ishihara، نويسنده , , Shunji and Amano، نويسنده , , Yuji and Nio، نويسنده , , Yoshinori and Higami، نويسنده , , Tetsuya and Kinoshita، نويسنده , , Yoshikazu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
5
From page
169
To page
173
Abstract
We investigated the frequency of BRAF mutations in human pancreatic cancer specimens to determine its role in the development of pancreatic cancer. Nine pancreatic cancer samples without a K-ras codon 12 mutation and 19 with a K-ras mutation were included in the study. Analyses of the BRAF sequence revealed mutations in exon 15 (V599E) in two cases, both of which also exhibited a K-ras codon 12 mutation. No BRAF mutation was found in cases without a K-ras mutation. The BRAF V599E mutation was not found to be a major mutation in pancreatic cancers that had no K-ras codon 12 mutation.
Keywords
pancreatic cancer , BRAF , K-ras , Mutation , Serine/threonine kinase
Journal title
Cancer Letters
Serial Year
2003
Journal title
Cancer Letters
Record number
1805539
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