Author/Authors :
Wang، نويسنده , , Luping and Yu، نويسنده , , Jiyao and Ni، نويسنده , , Jian and Xu، نويسنده , , Xue-Ming and Wang، نويسنده , , Jianjin and Ning، نويسنده , , Haoyong and Pei، نويسنده , , Xu-Fang and Chen، نويسنده , , Jinguo and Yang، نويسنده , , Shanmin and Underhill، نويسنده , , Charles B. and Liu، نويسنده , , Lei and Liekens، نويسنده , , Joeri and Merregaert، نويسنده , , Joseph and Zhang، نويسنده , , LuRong and Tang، نويسنده ,
Abstract :
The extracellular matrix protein 1 (ECM1) is a secreted protein that has been implicated with cell proliferation, angiogenesis and differentiation. In the present study, we used immunohistochemical staining to examine the expression of ECM1 in a panel of human tumors and found that it was closely correlated with some types of tumors including: invasive breast ductal carcinoma (83%), esophageal squamous carcinoma (73%), gastric cancer (88%) and colorectal cancer (78%). Significantly, ECM1expression was correlated with the metastatic properties of the tumors. Primary breast cancers that had formed metastases were 76% positive while those that had not metastasized were only 33% positive. ECM1 expression was also correlated with PCNA a marker for proliferation, but not with CD34, a marker for endothelial cells. These results indicate that ECM1 tends to be preferentially expressed by metastatic epithelial tumors.
Keywords :
Extracellular matrix protein 1 , Proliferation , metastasis , Endothelial cells
