Author/Authors :
Haddad، نويسنده , , Riad and Vincent، نويسنده , , John B. and Gryfe، نويسنده , , Robert and Kim، نويسنده , , Hyeja and Wen، نويسنده , , Joseph and Redston، نويسنده , , Mark and Scherer، نويسنده , , Stephen W. and Gallinger، نويسنده , , Steven، نويسنده ,
Abstract :
ST7 is a putative tumor suppressor gene on chromosome 7q31. However, the role of ST7 as a tumor suppressor is uncertain as somatic mutations have been difficult to demonstrate.
er to investigate the genetic role of RAY1/ST7 in tumorigenesis, we have screened 135 colorectal cancers for loss of heterozygosity (LOH) at chromosome 7q31.The entire RAY1/ST7 gene, including intron/exon boundaries and alternate 5′ and 3′ sequences of 15/124 (12%) informative cancers with LOH were characterized. No somatic mutations of the RAY1/ST7 gene were observed. Our results do not support a role for RAY1/ST7 as a colorectal cancer tumor suppressor gene.
Keywords :
Colon cancer , Loss of Heterozygosity , Microsatellite stable , Chromosome 7q31
