Author/Authors :
Niwa، نويسنده , , Yoshimitsu and Hamajima، نويسنده , , Nobuyuki and Atsuta، نويسنده , , Yoshiko and Yamamoto، نويسنده , , Kazuhito and Tamakoshi، نويسنده , , Akiko and Saito، نويسنده , , Toshiko and Hirose، نويسنده , , Kaoru and Nakanishi، نويسنده , , Toru and Nawa، نويسنده , , Akihiro and Kuzuya، نويسنده , , Kazuo and Tajima، نويسنده , , Kazuo، نويسنده ,
Abstract :
To examine the possible association between cervical cancer and p73 G4C14-to-A4T14 in exon 2 and p53 Arg72Pro polymorphisms, an incident case-control study was conducted in Japanese. The cases were 112 cervical cancer patients. Controls were 320 healthy women and 122 non-cancer female outpatients. Risk estimation for each genotype by an unconditional logistic model demonstrated a possible association between the p73 A4T14 variant and the risk of cervical cancer in our Japanese population (OR=1.57; 95%CI, 0.99–2.48, P=0.053). There was no significant difference in the p53 Arg72Pro genotype frequency between the controls and cases.
Keywords :
p73 two linked polymorphism , cervical cancer , Polymerase chain reaction with confronting two-pair primers , p53 Arg72Pro polymorphism
