Author/Authors :
Nikiforova، نويسنده , , Marina N and Ciampi، نويسنده , , Raffaele and Salvatore، نويسنده , , Giuliana and Santoro، نويسنده , , Massimo and Gandhi، نويسنده , , Manoj and Knauf، نويسنده , , Jeffrey G. and Thomas، نويسنده , , Gerry A and Jeremiah، نويسنده , , Stephen and Bogdanova، نويسنده , , Tatyana I and Tronko، نويسنده , , Mykola D and Fagin، نويسنده , , James A and Nikiforov، نويسنده , , Yuri E، نويسنده ,
Abstract :
Point mutations of the BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of BRAF point mutations and RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence (4%) of BRAF point mutations and high prevalence (58%) of RET/PTC rearrangements. Sporadic papillary carcinomas revealed a clearly distinct pattern, with 37% of tumors harboring BRAF mutations and 20% RET/PTC rearrangements. These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors.
Keywords :
Thyroid cancer , RET/PTC Rearrangement , BRAF mutation , Radiation exposure
