Title of article
Increased expression and altered location of annexin IV in renal clear cell carcinoma: a possible role in tumour dissemination
Author/Authors
Zimmermann، نويسنده , , Uwe and Balabanov، نويسنده , , Stefan and Giebel، نويسنده , , Jürgen and Teller، نويسنده , , Steffen and Junker، نويسنده , , Heike and Schmoll، نويسنده , , Dieter and Protzel، نويسنده , , Chris and Scharf، نويسنده , , Christian and Kleist، نويسنده , , Britta and Walther، نويسنده , , Reinhard، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
8
From page
111
To page
118
Abstract
The proteome of renal cell carcinoma and non-neoplastic kidney tissue was analysed from 12 patients by two-dimensional polyacrylamide gel electrophoresis to search for differentially expressed proteins in the tumour. Annexin IV was identified to be up-regulated in tumour cells. These patients and further 11 were characterized by RT-PCR. We found an increased amount of annexin IV mRNA. Immunohistochemical analysis revealed an altered localization of annexin IV in tumour cells. Additionally we demonstrate that over-expressed annexin IV promotes cell migration in a carcinoma model system. From these results above it seems possible that annexin IV plays an important role in the morphological diversification and dissemination of the clear cell renal cell carcinoma.
Keywords
Kidney tissue , Kidney cancer , RT-PCR , Annexin IV , Proteome , Cell migration , immunohistochemistry
Journal title
Cancer Letters
Serial Year
2004
Journal title
Cancer Letters
Record number
1806466
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