Author/Authors :
Hashimoto، نويسنده , , Tomoko and Uchida، نويسنده , , Kenichiro and Okayama، نويسنده , , Naoko and Imate، نويسنده , , Yuji and Suehiro، نويسنده , , Yutaka and Hamanaka، نويسنده , , Yuichiro and Ueyama، نويسنده , , Yoshiya and Shinozaki، نويسنده , , Fumihiko and Yamashita، نويسنده , , Hiroshi and Hinoda، نويسنده , , Yuji، نويسنده ,
Abstract :
To explore the relation of the MMP-1 1G/2G and MMP-3 5A/6A promoter polymorphisms with head and neck squamous cell carcinoma (HNSCC), DNA specimens extracted from peripheral blood cells of HNSCC patients and healthy controls were genotyped. The frequency of the MMP-1 2G/2G genotype was significantly higher in HNSCC patients (n=140) than in age- and sex-matched controls (n=223) (P=0.042; OR, 1.56). In the MMP-3 polymorphism, there was no significant difference in the genotype distribution between patients and controls. These data suggest that the MMP-1 promoter polymorphism may be associated with HNSCC.
Keywords :
Head and neck squamous cell carcinoma , Polymorphism , Matrix metalloproteinase-1 , Matrix metalloproteinase-3
