Title of article
Molecular signature linked to acquired resistance to cisplatin in esophageal cancer cells
Author/Authors
Toshimitsu، نويسنده , , Hiroaki and Hashimoto، نويسنده , , Kiichiro and Tangoku، نويسنده , , Akira and Iizuka، نويسنده , , Norio and Yamamoto، نويسنده , , Kohtaro and Kawauchi، نويسنده , , Shigeto and Oga، نويسنده , , Atsunori and Furuya، نويسنده , , Tomoko and Oka، نويسنده , , Masaaki and Sasaki، نويسنده , , Kohsuke، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
10
From page
69
To page
78
Abstract
To clarify the molecular basis of acquired cisplatin (CDDP) resistance in esophageal squamous cell carcinoma (ESCC), we used cDNA microarray technology. A CDDP-resistant cell line (YES-2/CDDP), which shows a 7.5-fold increase in resistance to CDDP and a 3-fold decrease in CDDP accumulation compared with the parental YES-2 ESCC cell line, was generated from YES-2 by exposure to increased concentrations of CDDP. By cDNA microarray analysis, we identified 44 genes with significantly different expression levels between YES-2/CDDP and YES-2 cells. Interestingly, 15 of these 44 genes encoded ribosome-related proteins, almost all of which were underexpressed in YES-2/CDDP cells. Our present data suggest that many ribosome-related genes may be involved in the acquired resistance to CDDP in ESCC and that such information may allow us to better understand the mechanism of CDDP resistance.
Keywords
Acquired CDDP-resistant cell line , cDNA microarray , ribosomal protein , comparative genomic hybridization
Journal title
Cancer Letters
Serial Year
2004
Journal title
Cancer Letters
Record number
1806671
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