Author/Authors :
de Azevedo Izidoro، نويسنده , , Ana Claudia Santos and Semprebom، نويسنده , , Andressa Marafon and Baboni، نويسنده , , Fernanda Brasil and Rosa، نويسنده , , Rosimeire Takaki and Machado، نويسنده , , Maria Angela Naval and Samaranayake، نويسنده , , Lakshman Perera and Rosa، نويسنده , , Edvaldo Antonio Ribeiro، نويسنده ,
Abstract :
It is widely accepted that tabagism is a predisposing factor to oral candidosis and cumulate data suggest that cigarette compounds may increase candidal virulence. To verify if enhanced virulence occurs in Candida albicans from chronic smokers, a cohort of 42 non-smokers and other of 58 smokers (all with excellent oral conditions and without signs of candidosis) were swabbed on tong dorsum and jugal mucosa. Results showed that oral candidal loads do not differ between smoker and non-smokers. Activities of secreted aspartyl-protease (Sap), phospholipase, chondroitinase, esterase–lipase, and haemolysin secretions were screened for thirty-two C. albicans isolates. There were detected significant increments in phospholipasic and chondroitinasic activities in isolates from non-smokers. For other virulence factors, no differences between both cohorts were achieved.
