Title of article
Elevated expression level of 60-kDa subunit of tRNA-guanine transglycosylase in colon cancer
Author/Authors
Ishiwata، نويسنده , , Shunji and Ozawa، نويسنده , , Yasuko and Katayama، نويسنده , , Jun-ichi Kaneko، نويسنده , , Shuko and Shindo، نويسنده , , Hiroki and Tomioka، نويسنده , , Yoshihisa and Ishiwata، نويسنده , , Toshiyuki and Asano، نويسنده , , Goro and Ikegawa، نويسنده , , Shigeo and Mizugaki، نويسنده , , Michinao، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
7
From page
113
To page
119
Abstract
tRNA-guanine transglycosylase (TGT) is an enzyme which synthesizes a modified nucleoside, queuosine, by exchanging the base moiety of guanosine for queuine in tRNA. We have reported that the expression level of the 60-kDa subunit of TGT (TGT60kD) is elevated in leukemic cells, however, there is no other report on the expression of TGT60kD in cancer cells. The expression levels of the TGT60kD protein are elevated in four of the five colon cancer cell lines and 83% of colon cancer tissues compared with normal tissues. The expression levels of the TGT60kD protein decreased in two colon cancer cell lines, after cell differentiation was induced. A marked positive staining of cancer cells in colon tissues was observed, and the subcellular staining pattern was mainly cytosolic. These data suggest that the role of TGT60kD in colon carcinogenesis.
Keywords
Colon cancer , queuosine , Expression , Differentiation , tRNA-guanine transglycosylase
Journal title
Cancer Letters
Serial Year
2004
Journal title
Cancer Letters
Record number
1806778
Link To Document