Author/Authors :
Puglisi، نويسنده , , Fabio and Minisini، نويسنده , , Alessandro Marco and Barbone، نويسنده , , Fabio and Intersimone، نويسنده , , Donatella and Aprile، نويسنده , , Giuseppe and Puppin، نويسنده , , Cinzia and Damante، نويسنده , , Giuseppe and Paron، نويسنده , , Igor and Tell، نويسنده , , Gianluca and Piga، نويسنده , , Andrea and Loreto، نويسنده , , Carla Di، نويسنده ,
Abstract :
Galectins are a family of animal β-galactoside-binding lectins involved in malignant transformation and progression. The present study evaluated the immunohistochemical expression of galectin-3 in a consecutive series of 81 radically resected non-small cell lung carcinomas (NSCLCs). The main pattern of galectin-3 expression was cytoplasmic (median percentage of cells with cytoplasmic positivity: 80.0%). The median percentage of tumor cells with nuclear and cytoplasmic co-expression of galectin-3 was 3.5%. No cases with exclusive nuclear immunostaining were observed. Functional interaction between galectin-3 and the thyroid transcription factor-1 (TTF-1) was previously demonstrated by cotransfection experiments. In the present study, concomitant expression of nuclear galectin-3 and TTF-1 was independently associated with a worse clinical outcome (HR 2.0; P=0.01).
