Title of article :
Lubricin in human temporomandibular joint disc: An immunohistochemical study
Author/Authors :
Leonardi، نويسنده , , Rosalia and Musumeci، نويسنده , , Giuseppe and Sicurezza، نويسنده , , Edoardo and Loreto، نويسنده , , Carla، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2012
Pages :
6
From page :
614
To page :
619
Abstract :
Aims luate, immunohistochemically, the presence and distribution of lubricin in human temporomandibular joint (TMJ) discs without any degenerative changes, obtained from autopsies, in order to elucidate the TMJ lubrication system and disc tribology. s histochemistry for lubricin detection was carried out on 34 TMJ discs. Any disc had signs of degenerative or inflammatory joint disease nor disc were displaced. Sections were incubated with diluted rabbit polyclonal anti-lubricin antibody and scored according to the percentage of lubricin immunopositive cells. Three different TMJ disc tissue compartments taken from the intermediate zone were analysed, namely: the central region as well as the temporal (superior) and condylar (inferior) disc surfaces. The Friedman test, was used to compare lubricin at a protein level expression, amongst the regions of disc specimens. s ng was noted within the TMJ disc cell populations in every disc tissue sample, however, the number of disc cells immunolabelled varied according to disc tissue regions. The percentage of immunostained cells, was statistically significant lower in the central region than in each disc surface (p < 0.0001), whilst any statistically significant difference was found when comparing the two surfaces one another. sions in is present in several location of TMJ disc being significantly more expressed at disc surfaces than in the central part.
Keywords :
Temporomandibular joint , chondrocyte , Osteoarthritis , Lubricin , Proteoglycan 4 (PRG4) , Superficial zone protein (SZP) , Disc
Journal title :
Archives of Oral Biology
Serial Year :
2012
Journal title :
Archives of Oral Biology
Record number :
1806936
Link To Document :
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