Author/Authors :
Liu، نويسنده , , Geoffrey and Zhou، نويسنده , , Wei and Wang، نويسنده , , Lisa I. and Park، نويسنده , , Sohee and Miller، نويسنده , , David P. and Xu، نويسنده , , Li Lian and Wain، نويسنده , , John C. and Lynch، نويسنده , , Thomas J. and Su، نويسنده , , Li and Christiani، نويسنده , , David C.، نويسنده ,
Abstract :
Manganese superoxide dismutase (SOD2) and myeloperoxidase (MPO) are polymorphic enzymes involved in reactive oxidative species metabolism. In this case-control study (830 non-small cell lung carcinoma (NSCLC) patients; 1119 controls) we evaluated whether the MPO −G463A polymorphism (associated with a novel estrogen receptor binding site) modifies the association between the SOD2 Ala16Val polymorphism and NSCLC risk differently by gender. For women carrying the MPO variant genotypes, the adjusted odds ratio of the SOD2 polymorphism (Val/Val vs. Ala/Ala) was 3.26 (95% CI, 1.55–6.83). No associations were found in men or in women carrying the MPO GG wildtype genotype.
Keywords :
SOD2 , GENDER , Polymorphism , MPO , lung cancer
