Title of article
Enhancement of sodium borocaptate (BSH) uptake by tumor cells induced by glutathione depletion and its radiobiological effect
Author/Authors
Yoshida، نويسنده , , Fumiyo and Matsumura، نويسنده , , Akira and Yamamoto، نويسنده , , Tetsuya and Kumada، نويسنده , , Hiroaki and Nakai، نويسنده , , Kei، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
7
From page
61
To page
67
Abstract
Sodium borocaptate (BSH) is widely used for boron neutron capture therapy (BNCT) of brain tumors. However, the mechanism of uptake by the tumor remains unclear. We investigated the sulfhydryl moiety of this compound. Down regulation of glutathione (GSH) by buthionine sulfoximine in cultured cells resulted in increase of BSH uptake (7.9–36.5%) compared to the control group and consequently the cytocidal effect of neutron irradiation also increased. On the other hand, the radiation caused damage by gamma-ray irradiation was suppressed when BSH uptake increased. These findings suggested that modulation of GSH enhanced the effect of B (n, α) reaction and the protective effect of secondary gamma-ray in BNCT.
Keywords
glutathione , Sodium borocaptate , Neutron , Buthionine sulfoximine , gamma-irradiation
Journal title
Cancer Letters
Serial Year
2004
Journal title
Cancer Letters
Record number
1807068
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