Author/Authors :
Chung، نويسنده , , Chih-Yuan and Yeh، نويسنده , , Kun-Tu and Hsu، نويسنده , , Nicholas C. and Chang، نويسنده , , Julia Huei-Mei and Lin، نويسنده , , Jen-Tsun and Horng، نويسنده , , Huey-Ching and Chang، نويسنده , , Cheng-Shyong، نويسنده ,
Abstract :
The expression of the c-kit protooncogene in human hepatocellular carcinoma (HCC) was investigated. Immunohistochemical staining (IHC) and RT-PCR were employed to examine the protein and mRNA expression of c-kit protooncogene, respectively. IHC results demonstrated that 22 of 86 (25.6%) HCC tissue sections expressed c-kit protein. The c-kit mRNA transcript was further confirmed in all 22 IHC c-kit positive HCC tissue samples by RT-PCR. Moreover, the relationship between c-kit expression in HCC and prognosis of patients was statistically analyzed and a correlation was established. The group of patients whose HCC specimens showed positive c-kit staining exhibited better survival as compared to those patients with negative c-kit expression (p=0.021). These results suggest that c-kit expression may be a good prognostic indicator for HCC.
