Author/Authors :
Niwa، نويسنده , , Yoshimitsu and Hirose، نويسنده , , Kaoru and Matsuo، نويسنده , , Keitaro and Tajima، نويسنده , , Kazuo and Ikoma، نويسنده , , Yoko and Nakanishi، نويسنده , , Toru and Nawa، نويسنده , , Akihiro and Kuzuya، نويسنده , , Kazuo and Tamakoshi، نويسنده , , Akiko and Hamajima، نويسنده , , Nobuyuki، نويسنده ,
Abstract :
To examine the possible association between cervical cancer and Lymphotoxin-α (LTα) polymorphisms, C804A and A252G, an incident case–control study was conducted in Japanese. The cases were 131 cervical cancer patients. Controls were 320 healthy women. Risk estimation was conducted by an unconditional logistic model. Complete linkage disequilibrium was seen between LTα C804A and LTα A252G. We found that, compared with the 804CC genotype, 804CA and 804AA were associated with a decreased risk of cervical cancer (OR=0.64, 95% CI=0.40–1.02; and OR=0.45, 95% CI=0.21–0.95, respectively), especially of SCC (OR=0.54, 95% CI=0.32–0.91; and OR=0.39, 95% CI=0.16–0.92, respectively).
Keywords :
LT? C804A polymorphism , LT? A252G polymorphism , cervical cancer , Polymerase chain reaction with confronting two-pair primers
