Author/Authors :
Kelemen، نويسنده , , Livia and Spurdle، نويسنده , , Amanda B. and Purdie، نويسنده , , David M. and Gertig، نويسنده , , Dorota and Chenevix-Trench، نويسنده , , Georgia، نويسنده ,
Abstract :
The RAD52 gene is involved in the homologous recombination repair pathway and is a plausible candidate ovarian cancer predisposition gene. We undertook a case–control comparison of 508 epithelial ovarian cancer cases (91 low malignant potential and 417 invasive) and 298 healthy controls to assess the RAD52 Y415X polymorphism as a risk factor for epithelial ovarian cancer in Australian women. Heterozygote frequencies of 2.6 and 4% were observed among cases and controls, respectively. The risk estimate was 0.55 (95%CI 0.24–1.24), suggesting that the RAD52 Y415X polymorphism is not associated with epithelial ovarian cancer in Australian women.
