Author/Authors :
Chang، نويسنده , , Bao-Li and Gillanders، نويسنده , , Elizabeth M. and Isaacs، نويسنده , , Sarah D. and Wiley، نويسنده , , Kathy E. and Adams، نويسنده , , Tamara and Turner، نويسنده , , Aubrey R. and Lilly Zheng، نويسنده , , and S. Mark Meyers، نويسنده , , Deborah A. and Carpten، نويسنده , , John D. and Walsh، نويسنده , , Patrick C. and Trent، نويسنده , , Jeffrey M. and Xu، نويسنده , , Jianfeng and Isaacs، نويسنده , , William B.، نويسنده ,
Abstract :
To identify genes that generally increase the risk of cancer, we performed a systematic search throughout the genome in 188 families primarily ascertained for prostate cancer but which also included individuals with other cancers. We observed significant evidence for linkage between susceptibility to all cancers and markers at 3p24, with a peak HLOD of 3.08 (P=0.0002). Compared to families with less than three other cancers and prostate cancer only, evidence for linkage at this region was stronger among families with at least three other cancers. This is the first reported example of a genome-wide search for general cancer susceptibility genes among hereditary prostate cancer families.
Keywords :
hereditary , Genome-wide scan , prostate cancer , CANCER , linkage
