Author/Authors :
Miki، نويسنده , , Yasuhiro and Suzuki، نويسنده , , Takashi and Tazawa، نويسنده , , Chika and Ishizuka، نويسنده , , Masato and Semba، نويسنده , , Shuho and Gorai، نويسنده , , Itsuo and Sasano، نويسنده , , Hironobu، نويسنده ,
Abstract :
The Müllerian ducts are strongly influenced by natural estrogen, estradiol (E2) and diethylstilbestrol (DES) in their development. We screened E2 and DES responsive genes using a microarray analysis in human primitive Müllerian duct cell line, EMTOKA cells expressed estrogen receptor (ER) β. c-myc oncogene and other target genes expression was detected in cells treated by high-dose DES, but ER antagonist ICI 182,780 could not prevent c-myc induction above. Results of our present study suggested the presence of ER independent pathway in oncogenes induction process by high-dose DES treatment in a human primitive Müllerian duct cell line.
Keywords :
estradiol , Microarray , Müllerian duct cell , c-Myc , Diethylstilbestrol (DES)
