Author/Authors :
Yang، نويسنده , , Young and Lee، نويسنده , , Jeong-Hyung and Yong Kim، نويسنده , , Kun and Keun Song، نويسنده , , Hyun and Kwang Kim، نويسنده , , Jae and Ran Yoon، نويسنده , , Suk and Cho، نويسنده , , Daeho and Sang Song، نويسنده , , Kyu and Ho Lee، نويسنده , , Young and Choi، نويسنده , , Inpyo and Ploberger، نويسنده ,
Abstract :
As an effort to identify immune suppressive molecules in gastric cancer cells, a signal sequence trap was employed. Among the genes identified, 9-27 gene was highly expressed in gastric tumor tissues and in cancer cell lines. It was induced by IFN-γ treatment, but not by TNF-α or TGF-β1 treatment. The overexpression of 9-27 in the gastric cancer cells rendered tumor cells more resistant to natural killer cells. In addition, the 9-27-overexpressed cells showed an increased migration and an invasive capacity when compared with the control cells. Taken together, these data indicate that 9-27 plays a role in malignant progression by suppressing natural killer cells and by increasing the invasive potential of gastric cancer cells.
Keywords :
9-27 , Natural Killer cell , Invasion , IFN-?
