Author/Authors :
Paragh، نويسنده , , Gyِrgy and Fَris، نويسنده , , Gabriella and Paragh Jr، نويسنده , , Gyِrgy and Seres، نويسنده , , Ildikَ and Karلnyi، نويسنده , , Zsolt and Fülِp، نويسنده , , Péter and Balogh، نويسنده , , Zoltلn and Kosztلczky، نويسنده , , Béla and Teichmann، نويسنده , , Farkas and Kertai، نويسنده , , Pلl، نويسنده ,
Abstract :
Rats (FLF1) were pretreated with 2 and 20 mg/kg/day fluvastatin (Flu), and after 6 weeks, hepatocellular tumor cells were inoculated under the left renal capsule. At different times, growth and pyruvate kinase (PK) activity of the primary tumors and lymph node metastases were determined. Flu had a dose-dependent inhibitory effect on primary and metastatic tumors, and the inhibitiory effect on growth and PK activity in metastases were higher than in primary tumors. Finally, Flu had an earlier inhibitory effect on the early appeared PK activity in metastases than in primary tumors.
Keywords :
Hepatocarcinoma , metastasis , Pyruvate kinase , Tumor growth inhibition , Fluvastatin , Rat
