Title of article :
Identification of a new target region by loss of heterozygosity at 5p15.33 in sporadic gastric carcinomas: genotype and phenotype related
Author/Authors :
Lu، نويسنده , , Yun and Yu، نويسنده , , Yingyan and Zhu، نويسنده , , Zhenggang and Xu، نويسنده , , Heng and Ji، نويسنده , , Jun and Bu، نويسنده , , Lei and Liu، نويسنده , , Bingya and Jiang، نويسنده , , Haisong and Lin، نويسنده , , Yanzhen and Kong، نويسنده , , Xiangyin and Hu، نويسنده , , Landian، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Pages :
9
From page :
329
To page :
337
Abstract :
Chromosome 5p, especially 5p15, involves in several cancers. To investigate its role in gastric cancer, we analyzed 46 intestinal-type and 34 diffuse-type gastric cancers by Loss of heterozygosity (LOH). We found a high frequent LOH at 5p15.33, and identified a minimal 2.7 cM candidate region of tumor suppressor gene, encompassing four loci (D5S417, D5S2849, D5S1492 and D5S2088). In total 80 cases, the highest LOH occurs at D5S2849 (35.19%). In intestinal-type cases, the highest LOH frequency is 50%, whereas in diffuse-type cases, the highest is only 16.67%. By statistical analysis we also observed an obvious genotype–phenotype correlation on 5p15.3 (P<0.01).
Keywords :
Chromosome 5p , Gastric cancer , Loss of Heterozygosity , Microsatellite marker
Journal title :
Cancer Letters
Serial Year :
2005
Journal title :
Cancer Letters
Record number :
1808138
Link To Document :
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