Author/Authors :
da Silva، نويسنده , , Tereza Cristina and Paula da Silva، نويسنده , , Ana and Akisue، نويسنده , , Gokithi and Luis Avanzo، نويسنده , , José and Kazumi Nagamine، نويسنده , , Mلrcia and Fukumasu، نويسنده , , Heidge and Matsuzaki، نويسنده , , Patrيcia and César Raspantini، نويسنده , , Paulo and Haraguchi، نويسنده , , Mitsue and Lima Gَrniak، نويسنده , , Silvana and Dagli، نويسنده , , Maria Lْcia Zaidan، نويسنده ,
Abstract :
Studies have been demonstrating Pfaffia paniculata root (Brazilian ginseng) anticarcinogenic activities. We evaluated its chemopreventive effects on preneoplastic hepatic lesions. BALB/c aged—15 days received 10 μg/g of diethylnitrosamine carcinogen, i.p. They were fed with the powdered root added to the diet: 0.5, 2 or 10% during 27 weeks. After being sacrificed, the macroscopic lesions in the livers were examined. Preneoplastic or neoplastic lesions were measured, quantified and classified morphologically. The treatment reduced the incidence, mean area and number of lesions, indicating an inhibitory effect of these roots on hepatocarcinogenesis promotion or progression steps.
Keywords :
hepatocarcinogenesis , Pfaffia paniculata , Liver , CANCER , chemoprevention
