Author/Authors :
Morandi، نويسنده , , Elena and Zingaretti، نويسنده , , Chiara and Chiozzotto، نويسنده , , Daniela and Severini، نويسنده , , Cinzia and Semeria، نويسنده , , Alessandro and Horn، نويسنده , , Wolfango and Vaccari، نويسنده , , Monica and Serra، نويسنده , , Roberto and Silingardi، نويسنده , , Paola and Colacci، نويسنده , , Annamaria، نويسنده ,
Abstract :
Chemotherapy, as generally available, is of a limited value in curing malignant brain tumors (gliomas), which often develop resistance to drugs, becoming completely unresponsive to any standard therapeutic approach. Camptothecins, a family of topoisomerase I inhibitor drugs, represent a new promising treatment strategy and are currently under evaluation for testing the clinical efficacy.
ected a CPT-resistant sub-line (U87CPT-R) from U87-MG grade III-IV astrocytoma cells, and compared the expression profile of the two cell lines by cDNA-microarray, as a preliminary screening of the molecular mechanisms involved in the acquisition of CPT resistance in glioma cells.
levant role of IL-1 beta overproduction as well as a generalised up-regulation of genes implicated in angiogenesis and inflammatory response are discussed in details.
Keywords :
camptothecin , Glioblastoma , cDNA-microarray , Drug resistance
