Title of article :
Hypericin-mediated photodynamic therapy elicits differential interleukin-6 response in nasopharyngeal cancer
Author/Authors :
Du، نويسنده , , Hongyan and Bay، نويسنده , , Boon-Huat and Mahendran، نويسنده , , Ratha and Olivo، نويسنده , , Malini، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
7
From page :
202
To page :
208
Abstract :
Cytokines induce inflammatory and immune responses in tumors after photodynamic therapy (PDT). Since there are no reports of IL-6 in nasopharyngeal cancer (NPC) cells following PDT, we evaluated IL-6 expression in two different NPC tumors after hypericin mediated PDT. Interleukin-6 transcription was significantly upregulated in PDT-treated CNE-2 poorly differentiated cells but not in HK1 well differentiated cells. In vivo, IL-6 mRNA expression was elevated in PDT-treated CNE-2 tumors but not in HK1 tumors. In conclusion, the study elucidated that the cell type, degree of histological differentiation and the basal expression of the cytokine influence the cytokine response following PDT.
Keywords :
IL-6 , cytokines , photodynamic therapy , Hypericin , PDT , Nasopharyngeal cancer , NPC , Interleukin-6 , CNE-2
Journal title :
Cancer Letters
Serial Year :
2006
Journal title :
Cancer Letters
Record number :
1809181
Link To Document :
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