Author/Authors :
Voho، نويسنده , , Anu and Metsola، نويسنده , , Katja and Anttila، نويسنده , , Sisko and Impivaara، نويسنده , , Olli and Jنrvisalo، نويسنده , , Jorma and Vainio، نويسنده , , Harri and Husgafvel-Pursiainen، نويسنده , , Kirsti and Hirvonen، نويسنده , , Ari، نويسنده ,
Abstract :
We investigated the roles of EPHX1 Tyr113His and His139Arg polymorphisms in lung cancer susceptibility in a Finnish study population comprising of 230 lung cancer cases and a large control group (n=2105). The controls were distributed into five age strata, which enabled us to examine the potential age-related changes in the putative EPHX1 at-risk genotypes in the cancer free population. Although the exon 3 slow activity associated allele (His113) containing genotypes posed a decreased lung cancer risk compared with the homozygous wild-type Tyr113/Tyr113 genotype (OR, 0.68; 95% CI, 0.49–0.94), no association was seen for the EPHX1 phenotypes interpreted from the combined exons 3 and 4 genotype data. Neither was any difference seen in the prevalence of the EPHX1 Tyr113His genotypes or interpreted EPHX1 phenotypes in the different age groups.
