Title of article
SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines
Author/Authors
Ryu، نويسنده , , Ji Kon and Lee، نويسنده , , Woo Jin and Lee، نويسنده , , Kwang Hyuck and Hwang، نويسنده , , Jin-Hyeok and Kim، نويسنده , , Yong-Tae and Yoon، نويسنده , , Yong-Bum and Kim، نويسنده , , Chung Yong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
12
From page
143
To page
154
Abstract
A novel hybrid synthetic histone deacetylase inhibitor, SK-7041, was synthesized from hydroaxamic acid of trichostatin A (TSA) and pyridyl ring of MS-275. TSA and SK-7041 both induced apoptosis and G2-M cell cycle arrest in pancreatic cancer cell lines. The expressions of p21 and cyclin D2 were up-regulated and that of cyclin B1 was down-regulated by TSA or SK-7041. The expression levels of Mcl-1 and Bcl-XL but not those of Bcl-2, Bax, and Bak were suppressed by TSA or SK-7041 treatment. SK-7041 or TSA induced apoptosis and G2-M cell cycle arrest by up-regulating p21 and down-regulating cyclin B1, Mcl-1, and Bcl-XL.
Keywords
apoptosis , cell cycle , pancreatic cancer , SK-7041 , Histone deacetylase inhibitor
Journal title
Cancer Letters
Serial Year
2006
Journal title
Cancer Letters
Record number
1809367
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