Author/Authors :
Mawrin، نويسنده , , Christian and Kirches، نويسنده , , Elmar and Diete، نويسنده , , Sabine and Wiedemann، نويسنده , , Falk R. and Schneider، نويسنده , , Thomas and Firsching، نويسنده , , Raimund and Kropf، نويسنده , , Siegfried and Bogerts، نويسنده , , Bernhard and Vorwerk، نويسنده , , Christian K. and Krüger، نويسنده , , Sabine and Dietzmann، نويسنده , , Knut، نويسنده ,
Abstract :
The FGFR4 codon 388 polymorphism (Arg388, Arg/Gly388 or Gly388) was determined in glioblastoma multiforme (GBM), anaplastic astrocytomas (AA), diffuse astrocytomas (DA), and control muscles. Arg388 was rare in AA, GBM, muscles, and was absent in DA. The Arg/Gly388 and the Gly388 frequency was equal among GBM and controls. FGFR4 expression was not related to codon 388 in GBM, and no survival differences between Arg/Gly388 and Gly388 tumors were found. U87 cells (Arg/Gly388) did not show higher invasion than U138 cells (Gly388). This suggests that the FGFR4 codon 388 status does not play a major role in malignant gliomas.
