Author/Authors :
Wang، نويسنده , , Jun and Wu، نويسنده , , Kaichun and Bai، نويسنده , , Feihu and Zhai، نويسنده , , Huihong and Xie، نويسنده , , Huahong and Du، نويسنده , , Yulei and Liang، نويسنده , , Jie and Han، نويسنده , , Shuang and Chen، نويسنده , , Yu and Lin، نويسنده , , Tao and Fan، نويسنده , , Daiming، نويسنده ,
Abstract :
We investigated the potential effect of Cyclooxygenase-2 (Cox-2) on hypoxia-induced Angiopoietin-2 (Ang-2) expression in gastric cancer cells. Our results revealed that hypoxia augmented Cox-2 and Ang-2 expressions. Also, the hypoxia-induced Ang-2 could be mimicked by CoCl2 treatment while genestein treatment could partially counteract the hypoxia-induced Ang-2 expression. Celecoxib but not Cox-1 inhibitor sc-560 reversed the hypoxia-induced Ang-2 expression, while this effect could be partially restored by addition of exogenous PGE2. Our findings suggest that the hypoxia-elevated Ang-2 expression in gastric cancer cells may be mediated by both Cox-2-derived PGE2 and HIF-1α pathways, while celecoxib could counteract the hypoxia-induced Ang-2 expression.
Keywords :
angiopoietin , cyclooxygenase , Gastric cancer , Hypoxia , Angiogenesis
