Author/Authors :
Miki، نويسنده , , Yasuhiro and Clyne، نويسنده , , Colin D. and Suzuki، نويسنده , , Takashi and Moriya، نويسنده , , Takuya and Shibuya، نويسنده , , Rie and Nakamura، نويسنده , , Yasuhiro and Ishida، نويسنده , , Takanori and Yabuki، نويسنده , , Nami and Kitada، نويسنده , , Kunio and Hayashi، نويسنده , , Shin-ichi and Sasano، نويسنده , , Hironobu، نويسنده ,
Abstract :
Summary
receptor homologue-1 (LRH-1) belongs to a class of nuclear orphan receptor. We examined immunolocalization of LRH-1 in 106 breast carcinomas. LRH-1 immunoreactivity was detected in 43% of the invasive ductal carcinoma. It was negatively correlated with clinical stage, histological grade and HER2 status, and positively associated with sex-steroid receptors, steroidogenic acute regulatory protein, P450 side-chain cleavage, and 3β-hydroxysteroid dehydrogenase. LRH-1 immunoreactivity was also detected in 28% of the ductal carcinoma in situ. These results suggest that LRH-1 is frequently detected in breast carcinoma tissues, and plays important roles including the regulation of in situ steroidogenesis.
