Author/Authors :
Badra، نويسنده , , Filitsa A. and Karamouzis، نويسنده , , Michalis V. and Ravazoula، نويسنده , , Panagiota and Likaki-Karatza، نويسنده , , Eleni and Tzorakoleftherakis، نويسنده , , Evagelos and Koukouras، نويسنده , , Dimitrios and Iconomou، نويسنده , , Gregorios and Xiros، نويسنده , , Nikolaos and Siablis، نويسنده , , Dimitrios V. Papavassiliou، نويسنده , , Athanasios G. and Kalofonos، نويسنده , , Haralabos P.، نويسنده ,
Abstract :
Malignant-appearing microcalcifications (MAMCs) represent one of the earliest mammographic findings of non-palpable breast carcinomas (NPBCs). In the present study, we have evaluated the expression of all EGFR family members in NPBCs and its possible association with MAMCs. Three hundred and fifty patients with non-palpable suspicious breast lesions detected during screening mammography were studied. EGFR family proteinsʹ expression was found to be present since the preclinical phase of breast carcinomas and was strongly correlated (except HER-3) with MAMCs. The co-expression pattern of EGFR family members combined with other molecular prognostic factors and the mammographic appearance might predict the natural history of NPBCs.
Keywords :
Non-palpable breast carcinomas , microcalcifications , mammography , EGFR
